Contrave is the combination of two older drugs: the antidepressant bupropion and the addiction-treatment drug naltrexone.
Its ads say the drug works on the brain to reduce hunger and control cravings. The Food and Drug Administration approved Contrave is for people with a body mass index of 27 or higher and who also suffer from serious conditions, such as heart disease, high blood pressure, high cholesterol or type-two diabetes.
The commercial cites studies in which patients took Contrave in addition to diet and exercise. The patients lost approximately two to four times more weight than those who did diet and exercise alone.
However, a Consumer Reports analysis of the three clinical trials used to gain FDA approval of the drug shows the drug works but the amount of additional weight loss is small and could pose serious health risks. Read More...